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Blood Purif. 2012;34(3-4):201-8.

Efficient removal of serum bilirubin by a novel artificial liver support system using albumin convection: a pilot study.

Author information

1
Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

Abstract

BACKGROUND/AIMS:

To compare the efficacy of a new artificial liver support system, fractionated plasma separation and adsorption integrated with hemofiltration, with the old system, plasma adsorption.

METHODS:

Sixteen patients with acute liver failure each received a first session of treatment using the old system, in which plasma was perfused through an adsorber. They then received a second session using the new system, in which albumin-rich plasma separated using a fraction plasma separator was ultrafiltrated using a hemofilter and perfused through an adsorber before being returned to blood.

RESULTS:

The new system had a higher clearance of bilirubin and slower decline of clearance over time. There was a lower reduction ratio of bilirubin, bile acid, urea, and creatinine; longer prolongation of coagulation parameters; and greater decline in albumin level using the old system compared with the new one.

CONCLUSIONS:

Use of the novel system results in more efficient removal of toxins and fewer deterious effects than the old system.

PMID:
23095438
DOI:
10.1159/000342111
[Indexed for MEDLINE]

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