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Behav Brain Sci. 2012 Oct;35(5):363-4. doi: 10.1017/S0140525X12001392.

Non-Mendelian etiologic factors in neuropsychiatric illness: pleiotropy, epigenetics, and convergence.

Author information

1
Eunice Kennedy Shriver Center, University of Massachusetts Medical School, Waltham, MA 02452, USA. curtis.deutsch@umassmed.edu

Abstract

The target article by Charney on behavior genetics/genomics discusses how numerous molecular factors can inform heritability estimations and genetic association studies. These factors find application in the search for genes for behavioral phenotypes, including neuropsychiatric disorders. We elaborate upon how single causal factors can generate multiple phenotypes, and discuss how multiple causal factors may converge on common neurodevelopmental mechanisms.

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PMID:
23095384
PMCID:
PMC3563321
DOI:
10.1017/S0140525X12001392
[Indexed for MEDLINE]
Free PMC Article

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