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Indian J Palliat Care. 2012 May;18(2):138-40. doi: 10.4103/0973-1075.100839.

Gabapentin in the treatment of persistent hiccups in advanced malignancy.

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Department of Pain Medicine and Palliative Care Services, Kokilaben Dhirubhai Ambani Hospital, Four bungalows, Andheri (West), Mumbai-53, India.


Hiccups are a distressing symptom in advanced malignancies in the setting of palliative care. A case of persistent hiccups treated with oral Gabapentin is presented to highlight the clinical and ethical dilemmas in patients with advanced malignancy. A 70-year-old male with non-small cell cancer of the lung with widespread metastases presented with persistent hiccups. The patient and family sought only symptom relief from home, without hospitalization or further investigations. The hiccups were dramatically relieved by oral Gabapentin, highlighting the recent reports that mention this molecule as being useful for hiccups. Gabapentin is a simple tool that may be utilized by palliative care physicians to relieve hiccups in advanced malignancies.


Gabapentin; Hiccups in malignancy; Persistent hiccups

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