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J Clin Invest. 2012 Nov;122(11):3852-4. doi: 10.1172/JCI66455. Epub 2012 Oct 24.

The promise of immune cell therapy for acute kidney injury.

Author information

1
Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. hrabb1@jhmi.edu

Abstract

Acute kidney injury (AKI) often results from ischemia reperfusion, sepsis, or exposure to nephrotoxins and is associated with a high rate of mortality and morbidity. Advances in understanding the pathophysiology of AKI may lead to the development of specific therapies. Although there is evidence of an important role for immune cells in AKI, the specific relevant populations and the mechanisms of their actions are unclear. In this issue of the JCI, Li et al. demonstrate that adenosine manipulates DC responses to kidney injury, raising hope that immunotherapy could be a tangible approach to AKI.

PMID:
23093787
PMCID:
PMC3484468
DOI:
10.1172/JCI66455
[Indexed for MEDLINE]
Free PMC Article

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