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Nucleic Acids Res. 2013 Jan 7;41(1):e31. doi: 10.1093/nar/gks968. Epub 2012 Oct 22.

X-inactivation: quantitative predictions of protein interactions in the Xist network.

Author information

1
Centre for Genomic Regulation, Dr Aiguader 88, 08003 Barcelona, Spain.

Abstract

The transcriptional silencing of one of the female X-chromosomes is a finely regulated process that requires accumulation in cis of the long non-coding RNA X-inactive-specific transcript (Xist) followed by a series of epigenetic modifications. Little is known about the molecular machinery regulating initiation and maintenance of chromosomal silencing. Here, we introduce a new version of our algorithm catRAPID to investigate Xist associations with a number of proteins involved in epigenetic regulation, nuclear scaffolding, transcription and splicing processes. Our method correctly identifies binding regions and affinities of protein interactions, providing a powerful theoretical framework for the study of X-chromosome inactivation and other events mediated by ribonucleoprotein associations.

PMID:
23093590
PMCID:
PMC3592426
DOI:
10.1093/nar/gks968
[Indexed for MEDLINE]
Free PMC Article

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