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Development. 2012 Nov;139(22):4105-9. doi: 10.1242/dev.074997.

Eph/ephrin signalling during development.

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1
Max-Planck Institute of Neurobiology, Department of Molecular Neurobiology, Am Klopferspitz 18, Munich-Martinsried, Germany. rklein@neuro.mpg.de

Abstract

Eph receptors and their membrane-tethered ligands have important functions in development. Trans interactions of Eph receptors with ephrins at cell-cell interfaces promote a variety of cellular responses, including repulsion, attraction and migration. Eph-ephrin signalling can be bi-directional and controls actin cytoskeleton dynamics, thereby leading to changes in cellular shape. This article provides an overview of the general structures and signalling mechanisms, and of typical developmental functions along with cell biological principles.

PMID:
23093422
DOI:
10.1242/dev.074997
[Indexed for MEDLINE]
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