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Rev Med Brux. 2012 Sep;33(4):212-4.

[Management of alcoholic hepatitis].

[Article in French]

Author information

1
Service de Gastroentérologie et d'Hépatopancréatologie, Hôpital Erasme et Laboratoire de Gastroentérologie Expérimentale, Faculté de Médecine, ULB, Bruxelles. tgustot@ulb.ac.be

Abstract

Alcoholic hepatitis is a severe form of alcoholic liver disease. Diagnosis is based on the association of new onset of jaundice and a compatible liver biopsy. Alcoholic hepatitis is severe when the Maddrey is up to 32 and, in this case, is associated with a mortality of 40-50% at 2 months. Corticosteroids improve survival of patients suffering from severe alcoholic hepatitis. The decrease of total bilirubin at day 7 of treatment and the Lille score are markers of response to corticosteroids. The absence of response is associated with a dramatic outcome (mortality rate of 75% at 6 months). Liver transplantation could be an alternative in a strictly selected group of non-responders.

PMID:
23091923
[Indexed for MEDLINE]
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