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J Clin Neurol. 2012 Sep;8(3):184-9. doi: 10.3988/jcn.2012.8.3.184. Epub 2012 Sep 27.

Anorectal manometric dysfunctions in newly diagnosed, early-stage Parkinson's disease.

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1
Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.

Abstract

BACKGROUND AND PURPOSE:

Anorectal dysmotility is common in advanced Parkinson's disease (PD), but there have been few evaluations in newly diagnosed PD patients.

METHODS:

We conducted anorectal manometric evaluations in 19 newly diagnosed, drug-naïve, early-stage PD patients. All of the PD patients were questioned regarding the presence of anorectal symptoms.

RESULTS:

Anorectal manometry was abnormal in 12 of the 19 patients. These abnormalities were more common in patients with more severe anorectal symptoms, as measured using a self-reported scale. However, more than 40% of patients with no or minimal symptoms also exhibited manometric abnormalities.

CONCLUSIONS:

These results suggest that anorectal dysmotility manifests in many early-stage PD patients, which this represent evidence for the involvement of neuronal structures in such nonmotor manifestations in PD.

KEYWORDS:

Parkinson's disease; anorectal dysfunction; manometry

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