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Small. 2013 Feb 11;9(3):387-92. doi: 10.1002/smll.201201363. Epub 2012 Oct 23.

Exposure to titanium dioxide nanoparticles induces autophagy in primary human keratinocytes.

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1
School of Materials Science and Engineering, Nanyang Technological University, Singapore.

Abstract

Understanding the mechanisms of cell-nanomaterial interactions is vital in harnessing the potential of using nanomaterials in biomedical applications. By immuno-labeling of LC3 and TEM analysis, it is found that titanium dioxide nanoparticles are internalized by human keratinocytes and induce autophagy. Autophagy appears to play a cytoprotective role in response to toxicity influence exerted by the nanoparticles.

PMID:
23090781
DOI:
10.1002/smll.201201363
[Indexed for MEDLINE]
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