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Antimicrob Agents Chemother. 2013 Jan;57(1):601-2. doi: 10.1128/AAC.01608-12. Epub 2012 Oct 22.

Daptomycin concentrations in valve tissue and vegetation in patients with bacterial endocarditis.

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1
U.O.C. Malattie Infettive, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy. c.tascini@ao-pisa.toscana.it

Abstract

In a patient with mitral-aortic native-valve Streptococcus oralis endocarditis, daptomycin concentrations in aortic and mitral valves were 8.6 and 30.8 μg/g, respectively, and 26 μg/g in the mitral vegetation. In the case of porcine-aortic-valve Staphylococcus epidermidis endocarditis, the daptomycin concentrations were 53.1 μg/g in the valve and 18.1 μg/g in perivalvular tissues. Daptomycin achieved apparently adequate tissue concentrations. S. epidermidis was eradicated, whereas Streptococcus oralis persisted, and its daptomycin MIC displayed a 4-fold increase.

PMID:
23089753
PMCID:
PMC3535905
DOI:
10.1128/AAC.01608-12
[Indexed for MEDLINE]
Free PMC Article
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