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J Med Chem. 2012 Nov 26;55(22):9531-40. doi: 10.1021/jm301217c. Epub 2012 Nov 2.

Novel 3-Azaindolyl-4-arylmaleimides exhibiting potent antiangiogenic efficacy, protein kinase inhibition, and antiproliferative activity.

Author information

1
Department of Pharmacy, Johannes Gutenberg University of Mainz, Mainz, Germany.

Abstract

Tumor growth and metastasis are highly associated with the overexpression of protein kinases (PKs) regulating cell growth, apoptosis resistance, and prolonged cell survival. This study describes novel azaindolyl-maleimides with significant inhibition of PKs, such as VEGFR, FLT-3, and GSK-3β which are related to carcinogenesis. Furthermore, these compounds exhibit high kinase selectivity and potent inhibition of angiogenesis and cell proliferation, offering versatile options in cancer treatment strategies.

PMID:
23088521
DOI:
10.1021/jm301217c
[Indexed for MEDLINE]

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