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J Infect Dis. 2013 Feb 15;207(4):588-93. doi: 10.1093/infdis/jis649. Epub 2012 Oct 19.

Use of oral fluid to examine the molecular epidemiology of varicella zoster virus in the United Kingdom and continental Europe.

Author information

1
University College London, London. mark.quinlivan@hotmail.com

Abstract

We investigated oral fluid (OF) as an alternative to sampling of rashes for varicella zoster virus (VZV) genotyping and further characterized VZV clade prevalence in the United Kingdom and Europe. VZV was detected in up to 91% of OF specimens. Paired OF and vesicle fluid samples contained identical VZV clades. While clades 1 and 3 were the most prevalent across the United Kingdom and Europe, in Western Europe, clade 5 viruses were circulating. Viruses from the same outbreak belonged to different clades, but no clade was associated with a severe-disease phenotype. OF is suitable and convenient for large-scale molecular epidemiological studies of VZV.

PMID:
23087434
PMCID:
PMC3549596
DOI:
10.1093/infdis/jis649
[Indexed for MEDLINE]
Free PMC Article

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