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J Biol Chem. 2012 Dec 14;287(51):42444-52. doi: 10.1074/jbc.R112.402768. Epub 2012 Oct 18.

From sirtuin biology to human diseases: an update.

Author information

1
Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA.

Abstract

Originally rising to notoriety for their role in the regulation of aging, sirtuins are a family of NAD(+)-dependent enzymes that have been connected to a steadily growing set of biological processes. In addition to regulating aging, sirtuins play key roles in the maintenance of organismal metabolic homeostasis. These enzymes also have primarily protective functions in the development of many age-related diseases, including cancer, neurodegeneration, and cardiovascular disease. In this minireview, we provide an update on the known roles for each of the seven mammalian sirtuins in these areas.

PMID:
23086954
PMCID:
PMC3522245
DOI:
10.1074/jbc.R112.402768
[Indexed for MEDLINE]
Free PMC Article

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