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Nat Neurosci. 2012 Nov;15(11):1485-7. doi: 10.1038/nn.3233. Epub 2012 Oct 21.

Neural progenitor cells regulate microglia functions and activity.

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1
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.

Abstract

We found mouse neural progenitor cells (NPCs) to have a secretory protein profile distinct from other brain cells and to modulate microglial activation, proliferation and phagocytosis. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at least some of these effects in mice. Thus, neural precursor cells may not only be shaped by microglia, but also regulate microglia functions and activity.

PMID:
23086334
PMCID:
PMC3495979
DOI:
10.1038/nn.3233
[Indexed for MEDLINE]
Free PMC Article

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