Format

Send to

Choose Destination
Nat Chem Biol. 2012 Dec;8(12):963-5. doi: 10.1038/nchembio.1095. Epub 2012 Oct 21.

The ydaO motif is an ATP-sensing riboswitch in Bacillus subtilis.

Author information

1
Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, USA.

Abstract

We report what is to our knowledge the first natural RNA that regulates gene expression in response to intracellular ATP. Using a biochemical screen, we found that several putative riboswitches bind ATP in vitro. The ydaO motif specifically bound ATP and regulated expression of endogenous and reporter genes in response to ATP concentrations in Bacillus subtilis. This discovery demonstrates a role for RNAs in regulating gene expression in response to energy balance in bacteria.

PMID:
23086297
DOI:
10.1038/nchembio.1095
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center