Format

Send to

Choose Destination
See comment in PubMed Commons below
Vaccine. 2013 May 17;31(21):2500-5. doi: 10.1016/j.vaccine.2012.10.016. Epub 2012 Oct 18.

Immune response to vaccine adjuvants during the first year of life.

Author information

1
Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. ofer.levy@childrens.harvard.edu

Abstract

Subunit vaccine formulations often include adjuvants that primarily stimulate innate immune cells. While young infants represent the major target population for vaccination, effective immunization in this age group remains a challenge. Many parameters of innate immune responses differ quantitatively and qualitatively from newborns to infants and adults, revealing a highly regulated developmental program. Herein, we discuss the potential implications of innate immune ontogeny for the activity of adjuvants contained in licensed infant vaccines, as well as future directions for rational design of adjuvanted vaccines for this age group.

PMID:
23085363
PMCID:
PMC4048858
DOI:
10.1016/j.vaccine.2012.10.016
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center