Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Host Microbe. 2012 Oct 18;12(4):470-83. doi: 10.1016/j.chom.2012.09.006.

Host translation at the nexus of infection and immunity.

Author information

1
Department of Microbiology, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA. ian.mohr@med.nyu.edu

Abstract

By controlling gene expression at the level of mRNA translation, organisms temporally and spatially respond swiftly to an ever-changing array of environmental conditions. This capacity for rapid response is ideally suited for mobilizing host defenses and coordinating innate responses to infection. Not surprisingly, a growing list of pathogenic microbes target host mRNA translation for inhibition. Infection with bacteria, protozoa, viruses, and fungi has the capacity to interfere with ongoing host protein synthesis and thereby trigger and/or suppress powerful innate responses. This review discusses how diverse pathogens manipulate the host translation machinery and the impact of these interactions on infection biology and the immune response.

PMID:
23084916
DOI:
10.1016/j.chom.2012.09.006
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center