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Cell Host Microbe. 2012 Oct 18;12(4):408-18. doi: 10.1016/j.chom.2012.10.002.

Innate immune sensing of HIV-1 by dendritic cells.

Author information

1
Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva, Switzerland. jeremy.luban@umassmed.edu

Abstract

HIV-1-specific antibodies and CD8(+) cytotoxic T cells are detected in most HIV-1-infected people, yet HIV-1 infection is not eradicated. Contributing to the failure to mount a sterilizing immune response may be the inability of antigen-presenting dendritic cells (DCs) to sense HIV-1 during acute infection, and thus the inability to effectively prime naive, HIV-1-specific T cells. Recent findings related to DC-expressed innate immune factors including SAMHD1, TREX1, and TRIM5 provide a molecular basis for understanding why DCs fail to adequately sense invasion by this deadly pathogen and suggest experimental approaches to improve T cell priming to HIV-1 in prophylactic vaccination protocols.

PMID:
23084911
PMCID:
PMC3619430
DOI:
10.1016/j.chom.2012.10.002
[Indexed for MEDLINE]
Free PMC Article

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