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Bioorg Med Chem Lett. 2012 Dec 1;22(23):7131-4. doi: 10.1016/j.bmcl.2012.09.073. Epub 2012 Oct 3.

Synthesis and antibiofilm activity of marine natural product-based 4-thiazolidinones derivatives.

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1
S.P.P. School of Pharmacy and Technology Management, NMIMS University, Vile Parle, Mumbai 400056, India. rajeshrane_uict@yahoo.co.in

Abstract

4-Thiazolidinones derivatives of marine bromopyrrole alkaloids were synthesized as potential antibiofilm compounds. Among the synthesized compounds, some showed promising antibiofilm activity. Biological data revealed that 1,3-thiazolidin-4-one derivatives are more potent antibiofilm agents compared to 1,3-thiazinan-4-ones. Antibiofilm activity of compound 4b, 4c (MIC=0.78 μg/ml) was 3-fold superior than standard vancomycin (MIC=3.125 μg/ml) while activity of compound 4d, 4f, 4g and 4h was 2-fold (MIC=1.56 μg/ml) against Staphylococcus aureus biofilm. Compound 4b-4h showed equal antibiofilm activity against Staphylococcus epidermidis compared to standard Vancomycin (MIC=3.125 μg/ml).

PMID:
23084904
DOI:
10.1016/j.bmcl.2012.09.073
[Indexed for MEDLINE]
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