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Trends Mol Med. 2012 Dec;18(12):689-90. doi: 10.1016/j.molmed.2012.10.002. Epub 2012 Oct 17.

Insights into tuberculosis from the zebrafish model.

Author information

1
Department of Molecular and Cell Biology, University of Washington, Seattle, WA 98195, USA.

Abstract

Mycobacterium tuberculosis (MTB) continues to plague humanity because of significant gaps in our understanding of MTB infection, including the nature of a protective versus pathological host response, why antimicrobial cure is so difficult, and the ineffectiveness of vaccination. The development of a zebrafish model, utilizing infection with the natural fish pathogen Mycobacterium marinum (Mm), has yielded important insights into tuberculosis with immediate clinical applications.

PMID:
23084762
DOI:
10.1016/j.molmed.2012.10.002
[Indexed for MEDLINE]

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