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Immunity. 2012 Oct 19;37(4):594-6. doi: 10.1016/j.immuni.2012.10.006.

The taming of the NF-κB: PP4R1 navigates while PP4c dephosphorylates.

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  • 1Howard Hughes Medical Institute, New York University School of Medicine, NY 10016, USA.


The NF-κB signaling pathway is important in the regulation of physiological and malignant hematopoiesis. In this issue of Immunity, Brechmann et al. (2012) identify a phosphatase, PP4R1, that inhibits NF-κB activation in T cells and T cell lymphoma.

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