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Gastrointest Endosc Clin N Am. 2012 Oct;22(4):639-60. doi: 10.1016/j.giec.2012.07.003. Epub 2012 Aug 30.

Pathophysiology of celiac disease.

Author information

1
University of Chicago Celiac Disease Center, Chicago, IL, USA. skupfer@medicine.bsd.uchicago.edu

Abstract

Celiac disease results from the interplay of genetic, environmental, and immunologic factors. An understanding of the pathophysiology of celiac disease, in which the trigger (wheat, rye, and barley) is known, will undoubtedly reveal basic mechanisms that underlie other autoimmune diseases (eg, type 1 diabetes) that share many common pathogenic perturbations. This review describes seminal findings in each of the 3 domains of the pathogenesis of celiac disease, namely genetics, environmental triggers, and immune dysregulation, with a focus on newer areas of investigation such as non-HLA genetic variants, the intestinal microbiome, and the role of the innate immune system.

PMID:
23083984
PMCID:
PMC3872820
DOI:
10.1016/j.giec.2012.07.003
[Indexed for MEDLINE]
Free PMC Article

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