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Neuron. 2012 Oct 18;76(2):266-80. doi: 10.1016/j.neuron.2012.10.002. Epub 2012 Oct 17.

The neuronal organization of the retina.

Author information

1
Department of Opthamology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA. richard_masland@meei.harvard.edu

Abstract

The mammalian retina consists of neurons of >60 distinct types, each playing a specific role in processing visual images. They are arranged in three main stages. The first decomposes the outputs of the rod and cone photoreceptors into ∼12 parallel information streams. The second connects these streams to specific types of retinal ganglion cells. The third combines bipolar and amacrine cell activity to create the diverse encodings of the visual world--roughly 20 of them--that the retina transmits to the brain. New transformations of the visual input continue to be found: at least half of the encodings sent to the brain (ganglion cell response selectivities) remain to be discovered. This diversity of the retina's outputs has yet to be incorporated into our understanding of higher visual function.

PMID:
23083731
PMCID:
PMC3714606
DOI:
10.1016/j.neuron.2012.10.002
[Indexed for MEDLINE]
Free PMC Article

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