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Angew Chem Int Ed Engl. 2013 Jan 2;52(1):325-30. doi: 10.1002/anie.201205721. Epub 2012 Oct 18.

Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation.

Author information

1
Department of Pharmacology, UCSD School of Medicine, University of California San Diego, La Jolla, USA.

Abstract

In real time: thrombin activation in vivo can be imaged in real time with ratiometric activatable cell penetrating peptides (RACPPs). RACPPs are designed to combine 1) dual-emission ratioing, 2) far red to infrared wavelengths for in vivo mammalian imaging, and 3) cleavage-dependent spatial localization. The most advanced RACPP uses norleucine (Nle)-TPRSFL as a linker that increases sensitivity to thrombin by about 90-fold.

PMID:
23080482
PMCID:
PMC3694763
DOI:
10.1002/anie.201205721
[Indexed for MEDLINE]
Free PMC Article

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