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Nat Rev Neurosci. 2012 Nov;13(11):798-810. doi: 10.1038/nrn3353.

The BCM theory of synapse modification at 30: interaction of theory with experiment.

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1
Institute for Brain and Neural Systems, Department of Physics, Brown University, Providence, Rhode Island 02912, USA. leon_cooper@brown.edu

Abstract

Thirty years have passed since the publication of Elie Bienenstock, Leon Cooper and Paul Munro's 'Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex', known as the BCM theory of synaptic plasticity. This theory has guided experimentalists to discover some fundamental properties of synaptic plasticity and has provided a mathematical structure that bridges molecular mechanisms and systems-level consequences of learning and memory storage.

PMID:
23080416
DOI:
10.1038/nrn3353
[Indexed for MEDLINE]
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