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Inflamm Res. 2012 Dec;61(12):1295-7. doi: 10.1007/s00011-012-0565-0. Epub 2012 Oct 19.

Decrease of cerebral mast cell degranulation after systemic administration of lipopolysaccharide.

Author information

1
Laboratory of Neurophysics and Physiology, CNRS UMR 8119, Paris Descartes University, 45 Rue Des Saints Pères, 75270 Paris, France.

Abstract

INTRODUCTION:

The mast cell is an immunocyte, but its functions in the brain remain unclear.

MATERIALS AND METHODS:

In a rat model of weak inflammation, we analyzed the effect of a gram-negative bacterial lipopolysaccharide injection (100 μg/kg) on thalamic mast cell (MC) population.

CONCLUSION:

We demonstrate a significant decrease of their degranulation, which suggests the implication of MC in preventing sepsis on the brain.

PMID:
23080081
DOI:
10.1007/s00011-012-0565-0
[Indexed for MEDLINE]

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