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BJOG. 2012 Dec;119(13):1617-23. doi: 10.1111/j.1471-0528.2012.03495.x. Epub 2012 Oct 19.

Vitamin D status and recurrent preterm birth: a nested case-control study in high-risk women.

Author information

1
Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7570, USA. thorp@med.unc.edu

Abstract

OBJECTIVE:

To determine whether vitamin D status is associated with recurrent preterm birth, and any interactions between vitamin D levels and fish consumption.

DESIGN:

A nested case-control study, using data from a randomised trial of omega-3 fatty acid supplementation to prevent recurrent preterm birth.

SETTING:

Fourteen academic health centres in the USA.

POPULATION:

Women with prior spontaneous preterm birth.

METHODS:

In 131 cases (preterm delivery at <35 weeks of gestation) and 134 term controls, we measured serum 25-hydroxyvitamin D [25(OH)D] concentrations by liquid chromatography-tandem mass spectrometry (LC-MS) from samples collected at baseline (16-22 weeks of gestation). Logistic regression models controlled for study centre, maternal age, race/ethnicity, number of prior preterm deliveries, smoking status, body mass index, and treatment.

MAIN OUTCOME MEASURES:

Recurrent preterm birth at <37 and <32 weeks of gestation.

RESULTS:

The median mid-gestation serum 25(OH)D concentration was 67 nmol/l, and 27% had concentrations of <50 nmol/l. Serum 25(OH)D concentration was not significantly associated with preterm birth (OR 1.33; 95% CI 0.48-3.70 for lowest versus highest quartiles). Likewise, comparing women with 25(OH)D concentrations of 50 nmol/l, or higher, with those with <50 nmol/l generated an odds ratio of 0.80 (95% CI 0.38-1.69). Contrary to our expectation, a negative correlation was observed between fish consumption and serum 25(OH)D concentration (-0.18, P < 0.01).

CONCLUSIONS:

In a cohort of women with a prior preterm birth, vitamin D status at mid-pregnancy was not associated with recurrent preterm birth.

PMID:
23078336
PMCID:
PMC3546544
DOI:
10.1111/j.1471-0528.2012.03495.x
[Indexed for MEDLINE]
Free PMC Article

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