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Eur J Cardiovasc Nurs. 2013 Aug;12(4):377-84. doi: 10.1177/1474515112459601. Epub 2012 Oct 16.

Higher dietary lycopene intake is associated with longer cardiac event-free survival in patients with heart failure.

Author information

1
College of Nursing, University of Kentucky, Lexington, KY 40536, USA. mjbidd0@uky.edu

Abstract

BACKGROUND:

The antioxidant lycopene may be beneficial for patients with heart failure (HF). Processed tomato products are a major source of lycopene, although they are also high in sodium. Increased sodium intake may counter the positive antioxidant effect of lycopene.

METHODS:

This was a prospective study of 212 patients with HF. Dietary intake of lycopene and sodium was obtained from weighted 4-day food diaries. Patients were grouped by the median split of lycopene of 2471 µg/day and stratified by daily sodium levels above and below 3 g/day. Patients were followed for 1 year to collect survival and hospitalization data. Cox proportional hazards modeling was used to compare cardiac event-free survival between lycopene groups within each stratum of sodium intake.

RESULTS:

Higher lycopene intake was associated with longer cardiac event-free survival compared with lower lycopene intake (p = 0.003). The worst cardiac event-free survival was observed in the low lycopene intake group regardless of sodium intake (> 3 g/day HR = 3.01; p = 0.027 and ≤ 3 g/day HR= 3.34; p = 0.023).

CONCLUSION:

These findings suggest that increased lycopene intake has the potential to improve cardiac event-free survival in patients with HF independent of sodium intake.

KEYWORDS:

Lycopene; antioxidants; heart failure; sodium

PMID:
23076979
PMCID:
PMC3612128
DOI:
10.1177/1474515112459601
[Indexed for MEDLINE]
Free PMC Article

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