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BMJ Case Rep. 2012 Oct 12;2012. pii: bcr2012007180. doi: 10.1136/bcr-2012-007180.

Unexpected remission of hepatocellular carcinoma (HCC) with lung metastasis to the combination therapy of thalidomide and cyproheptadine: report of two cases and a preliminary HCC cell line study.

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1
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan.

Abstract

We reported two cases of hepatocellular carcinoma (HCC) with lung metastases who were treated with a combination of thalidomide and cyproheptadine. The use of cyproheptadine in these two cases was originally for skin itching. Follow-up CT images revealed a complete remission of HCC in both of them after treatment for 6 months and 6 weeks, respectively. A following experimental cell line study demonstrated that cyproheptadine effectively reduced the viability of two HCC cell lines.

PMID:
23076705
PMCID:
PMC4543862
DOI:
10.1136/bcr-2012-007180
[Indexed for MEDLINE]
Free PMC Article
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