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Virulence. 2012 Aug 15;3(5):421-33. doi: 10.4161/viru.21282. Epub 2012 Aug 15.

Intrinsic and acquired resistance mechanisms in enterococcus.

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1
Department of Medicine, Lifespan/Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA.

Abstract

Enterococci have the potential for resistance to virtually all clinically useful antibiotics. Their emergence as important nosocomial pathogens has coincided with increased expression of antimicrobial resistance by members of the genus. The mechanisms underlying antibiotic resistance in enterococci may be intrinsic to the species or acquired through mutation of intrinsic genes or horizontal exchange of genetic material encoding resistance determinants. This paper reviews the antibiotic resistance mechanisms in Enterococcus faecium and Enterococcus faecalis and discusses treatment options.

PMID:
23076243
PMCID:
PMC3485979
DOI:
10.4161/viru.21282
[Indexed for MEDLINE]
Free PMC Article
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