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Cell Adh Migr. 2012 Nov-Dec;6(6):518-25. doi: 10.4161/cam.22139. Epub 2012 Oct 17.

Regulation of synaptojanin 2 5'-phosphatase activity by Src.

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1
Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research at North Shore-LIJ, Manhasset, NY, USA.

Abstract

Synaptojanin 2 (SYNJ2) is a phosphatidylinositol (PI) phosphatase that controls two distinct functions, clathrin-mediated endocytosis and tumor cell invadopodia formation and invasion. Here, we identify a number of novel SYNJ2 binding partners, several of which have previously been shown to be necessary for invadopodia formation or clathrin-mediated endocytosis. We focus on Src family kinases. We found that Src phosphorylates SYNJ2 on Tyr ( 490) , thereby stimulating SYNJ2 5'-phosphatase activity in vitro. We also provide evidence that Src-mediated phosphorylation of SYNJ2 contributes to invadopodia formation.

PMID:
23076136
PMCID:
PMC3547897
DOI:
10.4161/cam.22139
[Indexed for MEDLINE]
Free PMC Article
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