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Cell Adh Migr. 2012 Sep-Oct;6(5):442-9. doi: 10.4161/cam.21832. Epub 2012 Sep 1.

Molecular insights on context-specific role of profilin-1 in cell migration.

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1
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.

Abstract

Profilin-1 (Pfn1) is a ubiquitously expressed actin-monomer binding protein that has been linked to many cellular activities ranging from control of actin polymerization to gene transcription. Traditionally, Pfn1 has been considered to be an essential control element for actin polymerization and cell migration. Seemingly contrasting this view, a few recent studies have shown evidence of an inhibitory action of Pfn1 on motility of certain types of carcinoma cells. In this review, we summarize biochemistry and functional aspects of Pfn1 in normal cells and bring in newly emerged action of Pfn1 in cancer cells that may explain its context-specific role in cell migration.

PMID:
23076048
PMCID:
PMC3496682
DOI:
10.4161/cam.21832
[Indexed for MEDLINE]
Free PMC Article
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