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Chem Commun (Camb). 2012 Dec 4;48(93):11410-2. doi: 10.1039/c2cc36366f. Epub 2012 Oct 17.

Modulation of the current signatures of DNA abasic site adducts in the α-hemolysin ion channel.

Author information

1
Department of Chemistry, University of Utah, Salt Lake City, USA.

Abstract

Electrical current signatures of DNA adducts were investigated during immobilization of strands inside the membrane-bound α-hemolysin ion channel. The current blockages produced by these adducts were found to depend on both size and shape, providing insights into the DNA-protein interactions and the size limitation of bulky adducts to be translocated.

PMID:
23076012
PMCID:
PMC3738171
DOI:
10.1039/c2cc36366f
[Indexed for MEDLINE]
Free PMC Article

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