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Case Rep Genet. 2011;2011:143132. doi: 10.1155/2011/143132. Epub 2011 Dec 1.

Monoclonal Gammopathy of Undetermined Significance (MGUS) in a Man with Fragile X-associated Tremor/Ataxia Syndrome.

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Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, Davis Medical Center, University of California, 2825 50th Street, Sacramento, CA 95817, USA ; Division of Human Genetics, Center for Biomedical Research, Faculty of Medicine, Diponegoro University, Jalan Dr. Sutomo No. 14, Semarang 50321, Indonesia.


We report the clinical presentation and laboratory findings of a 69-year-old man with fragile X-associated tremor ataxia syndrome (FXTAS), a progressive neurodegenerative disorder, who was noted to have monoclonal gammopathy of undetermined significance (MGUS), a plasma cell proliferative disorder and a precursor disease of multiple myeloma. Both MGUS and FXTAS are associated with microRNA (miRNA) dysregulation. We speculate that individuals with FXTAS may be predisposed to MGUS and further studies are warranted regarding this association.

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