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Oman Med J. 2012 Sep;27(5):413-4. doi: 10.5001/omj.2012.101.

No more milk in milk-alkali syndrome: a case report.

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McMaster University, Hamilton, Ontario, Canada.


This is a case of Milk-AlKali syndrome in a patient who presented with the classical triad of hypercalcemia, metabolic alkalosis and renal impairment. The source of calcium was over-the-counter calcium-containing antacid (TumsĀ®). Milk-alkali syndrome was first recognized secondary to treatment of peptic ulcer disease with milk and absorbable alkali. Its incidence fell after the introduction of H2-blocker and proton pump inhibitor. However, it is one of the leading causes of hypercalcemia nowadays because of the wide availability, increased marketing and use of calcium carbonate especially in osteoporosis prevention and treatment. The demographics of milk-alkali syndrome have changed compared to when it was initially described. The presentation could be acute, subacute or chronic. Early diagnosis, discounting calcium supplement and intravenous hydration are the mainstay of MAS management.


Calcium-alkali syndrome; Hypercalcemia; MAS; Milk-alkali syndrome

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