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Yonsei Med J. 2012 Nov 1;53(6):1120-7. doi: 10.3349/ymj.2012.53.6.1120.

High dose involved field radiation therapy as salvage for loco-regional recurrence of non-small cell lung cancer.

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1
Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, Korea.

Abstract

PURPOSE:

To determine the effectiveness of salvage radiation therapy (RT) in patients with loco-regional recurrences (LRR) following initial complete resection of non-small cell lung cancer (NSCLC) and assess prognostic factors affecting survivals.

MATERIALS AND METHODS:

Between 1994 and 2007, 64 patients with LRR after surgery of NSCLC were treated with high dose RT alone (78.1%) or concurrent chemo-radiation therapy (CCRT, 21.9%) at Samsung Medical Center. Twenty-nine patients (45.3%) had local recurrence, 26 patients (40.6%) had regional recurrence and 9 patients (14.1%) had recurrence of both components. The median RT dose was 54 Gy (range, 44-66 Gy). The radiation target volume included the recurrent lesions only.

RESULTS:

The median follow-up time from the start of RT in survivors was 32.0 months. The rates of in-field failure free survival, intra-thoracic failure free survival and extra-thoracic failure free survival at 2 years were 52.3%, 33.9% and 59.4%, respectively. The median survival after RT was 18.5 months, and 2-year overall survival (OS) rate was 47.9%. On both univariate and multivariate analysis, the interval from surgery till recurrence and CCRT were significant prognostic factors for OS.

CONCLUSION:

The current study demonstrates that involved field salvage RT is effective for LRR of NSCLC following surgery.

PMID:
23074111
PMCID:
PMC3481375
DOI:
10.3349/ymj.2012.53.6.1120
[Indexed for MEDLINE]
Free PMC Article
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