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Chem Commun (Camb). 2012 Nov 28;48(92):11352-4. doi: 10.1039/c2cc36334h.

Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase.

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1
Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province 210009, People's Republic of China.

Abstract

Diketoreductase catalyzes a two-step bioreduction on a dicarbonyl substrate through a novel dual catalysis mode, in which random hydride attack simultaneously forms two mono-carbonyl intermediates, and subsequently distinct catalytic sites are responsible for the reductions of respective carbonyl group of the intermediates to yield the final dihydroxy product.

PMID:
23073461
DOI:
10.1039/c2cc36334h
[Indexed for MEDLINE]
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