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EMBO J. 2012 Nov 28;31(23):4373-4. doi: 10.1038/emboj.2012.290. Epub 2012 Oct 16.

Life or death: developing cortical interneurons make their own decision.

Author information

1
Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Abstract

During nervous system development, programmed cell death is considered as an essential adaptive process. The mechanism by which the number of mature neurons is determined in the central nervous system is not well understood. In a recent Nature paper, Southwell et al (2012) demonstrate that cortical GABAergic interneuron cell death is intrinsically determined without the need to compete for extrinsic survival signals derived from other cell types.

PMID:
23073347
PMCID:
PMC3512393
DOI:
10.1038/emboj.2012.290
[Indexed for MEDLINE]
Free PMC Article
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