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Nat Rev Mol Cell Biol. 2012 Nov;13(11):700-12. doi: 10.1038/nrm3454. Epub 2012 Oct 17.

NMD: a multifaceted response to premature translational termination.

Author information

1
Centre National de la Recherche Scientifique UPR9073, Université Paris Diderot Sorbonne Paris Cité, Institut de Biologie Physico-chimique, Paris, France.

Abstract

Although most mRNA molecules derived from protein-coding genes are destined to be translated into functional polypeptides, some are eliminated by cellular quality control pathways that collectively perform the task of mRNA surveillance. In the nonsense-mediated decay (NMD) pathway premature translation termination promotes the recruitment of a set of factors that destabilize a targeted mRNA. The same factors also seem to have key roles in repressing the translation of the mRNA, dissociating its terminating ribosome and messenger ribonucleoproteins (mRNPs), promoting the degradation of its truncated polypeptide product and possibly even feeding back to the site of transcription to interfere with splicing of the primary transcript.

PMID:
23072888
PMCID:
PMC3970730
DOI:
10.1038/nrm3454
[Indexed for MEDLINE]
Free PMC Article

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