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Scand J Clin Lab Invest. 2012 Dec;72(8):623-8. doi: 10.3109/00365513.2012.726370. Epub 2012 Oct 16.

Decreased synovial fluid omentin-1 concentrations reflect symptomatic severity in patients with knee osteoarthritis.

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1
Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian, Liaoning, PR China.

Abstract

The aim of this study was to measure omentin-1 concentrations in serum and synovial fluid (SF) of knee osteoarthritis (OA) patients and to investigate their correlation with patient-reported symptomatic severity. We enrolled 263 knee OA patients and 62 healthy controls. We collected Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores from OA patients and measured omentin-1 concentrations in serum and SF by enzyme-linked immunosorbent assay (ELISA). Our results demonstrated that omentin-1 concentrations in SF but not serum were independently and negatively correlated with self-reported greater pain and physical disability in OA patients. Omentin-1 in SF might serve as a potential biomarker for reflecting the symptomatic severity of OA.

PMID:
23072466
DOI:
10.3109/00365513.2012.726370
[Indexed for MEDLINE]
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