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Clin Microbiol Infect. 2012 Dec;18(12):E548-51. doi: 10.1111/1469-0691.12034. Epub 2012 Oct 17.

Analysis of the circulation of hepatitis A virus in Argentina since vaccine introduction.

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1
Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires - CONICET, Argentina.

Abstract

Hepatitis A virus (HAV) has shown intermediate endemicity in Argentina, but its incidence has decreased since vaccine introduction in 2005. Environmental surveillance was conducted in five rivers from Argentina from 2005 to 2012, complementing clinical information. HAV detection decreased since 2005, although its circulation continues, maintaining viral diversity but not undergoing antigenic drift. Most sequences belonged to subgenotype IA, closely related to Argentinean clinical sequences, but one belonged to proposed subgenotype IC, previously undetected in the country. Environmental surveillance might contribute to monitoring the single-dose vaccination schedule, representing not only strains causing disease but also the circulating population and the viral introductions.

PMID:
23072283
DOI:
10.1111/1469-0691.12034
[Indexed for MEDLINE]
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