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Int J Pharm Investig. 2011 Oct;1(4):222-6. doi: 10.4103/2230-973X.93009.

A novel herbal formulation in the management of diabetes.

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1
Padmashree Dr. D.Y.Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, India.

Abstract

BACKGROUND AND AIM:

Momordica charantia Linn. is traditionally used as a medicine for diabetes. The present investigation was aimed to formulate and evaluate transdermal patchesof Momordica charantia Linn.

MATERIALS AND METHODS:

The transdermal films containing the herbal drug component fractionated fromethanolicextract of M. charantia fruits were prepared by using hydroxy propyl methyl cellulose as a polymer. The films were evaluated for folding endurance, thickness, weight variation, drug contents and in vitro diffusion studies and in vivo parameterslike acute and sub-acute antihyperglycemic activity in diabetic rats, biochemicalstudies, skin irritation in rats and stability studies.

RESULT AND DISCUSSION:

The weightof transdermal patches of M. charantia (2 cm(2); 10 mg/patch) and was found to be 0.03 gm.Thickness of patches of M. charantia (2 cm(2); 10 mg/patch) was found to be satisfactory. The percentage release of active constituents from transdermal patches of M.charantia (2 cm(2); 10 mg/patch) was found to be 47.59% in 10% hydroalcoholic phosphate buffer pH 7.4 at the end of 6 h.The transdermal route exhibited negligible skin irritation and in vivo results revealed that the patches successfully decrease the blood glucose level.

CONCLUSION:

From the results, we concluded that the well-known herbal drug M. charantia Linn. have been found to be effective for diabetes through modern pharmaceutical formulation techniques.

KEYWORDS:

Diabetes mellitus; M. charantia Linn; diethyl ether fraction; transdermal patch

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