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Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):17931-5. doi: 10.1073/pnas.1215241109. Epub 2012 Oct 15.

Structure of the mediator head module bound to the carboxy-terminal domain of RNA polymerase II.

Author information

1
Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

The X-ray crystal structure of the Head module, one-third of the Mediator of transcriptional regulation, has been determined as a complex with the C-terminal domain (CTD) of RNA polymerase II. The structure reveals multiple points of interaction with an extended conformation of the CTD; it suggests a basis for regulation by phosphorylation of the CTD. Biochemical studies show a requirement for Mediator-CTD interaction for transcription.

PMID:
23071300
PMCID:
PMC3497735
DOI:
10.1073/pnas.1215241109
[Indexed for MEDLINE]
Free PMC Article

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