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Nanoscale. 2012 Nov 21;4(22):7127-34. doi: 10.1039/c2nr31901b.

Controlling the nano-bio interface to build collagen-silica self-assembled networks.

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UPMC Univ Paris 06, CNRS, Chimie de la Matière Condensée de Paris Collège de France, 11 place Marcelin Berthelot, F-75005 Paris, France.


Bio-hybrid networks are designed based on the self-assembly of surface-engineered collagen-silica nanoparticles. Collagen triple helices can be confined on the surface of sulfonate-modified silica particles in a controlled manner. This gives rise to hybrid building blocks with well-defined diameters and surface potentials. Taking advantage of the self-assembling properties of collagen, collagen-silica networks are further built-up in solution. The structural and specific recognition properties of the collagen fibrils are well-preserved within the hybrid assembly. A combination of calorimetry, dynamic light scattering, zetametry and microscopy studies indicates that network formation occurs via a surface-mediated mechanism where pre-organization of the protein chains on the particle surface favors the fibrillogenesis process. These results enlighten the importance of the nano-bio interface on the formation and properties of self-assembled bionanocomposites.

[Indexed for MEDLINE]

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