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Antimicrob Agents Chemother. 2013 Jan;57(1):597-600. doi: 10.1128/AAC.01081-12. Epub 2012 Oct 15.

Complete sequence of pJIE186-2, a plasmid carrying multiple virulence factors from a sequence type 131 Escherichia coli O25 strain.

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1
Center of Infectious Diseases, West China Hospital, Sichuan University, and Division of Infectious Diseases, the State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China. zongzhiy@scu.edu.cn

Abstract

The complete sequence of a 137-kb plasmid, pJIE186-2, from a sequence type 131 (ST131) Escherichia coli strain was determined. pJIE186-2 contained IncF replicons (FIB, FIIA, and FIAΔ), an incomplete conjugative region, and multiple virulence factors (sitABCD, iucABCD-iutA, iroCDEN, etsABC, hlyF, iss, ompT, and vagCD) but no antimicrobial resistance genes. The host strain also had another plasmid, pJIE186-1, carrying multiple resistance genes. The two plasmids conferred selective advantages for the host strain, contributing to the recent emergence of ST131 E. coli.

PMID:
23070168
PMCID:
PMC3535984
DOI:
10.1128/AAC.01081-12
[Indexed for MEDLINE]
Free PMC Article
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