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J Pharm Bioallied Sci. 2012 Aug;4(Suppl 2):S230-3. doi: 10.4103/0975-7406.100214.

Triple antibiotic paste in root canal therapy.

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Department of Pedodontics and Reventive Dentistry, Vivekanandha Dental College for Women, Tiruchengode, Tamil Nadu, India.


The success of the endodontic treatment depends on the microbial suppression in the root canal and periapical region. Endodontic instrumentation alone cannot achieve a sterile condition. With the advent of non-instrumentation endodontic treatment and lesion sterilization and tissue repair, local application of antibiotics has been investigated. Triple antibiotic paste (TAP) containing metronidazole, ciprofloxacin, and minocycline has been reported to be a successful regimen in controlling the root canal pathogen and in managing non-vital young permanent tooth. This paper reviews the existing literature on biocompatibility, efficiency, drawbacks of TAP in endodontic therapy and pulp revascularization.


Non-vital; triple antibiotic paste; young permanent tooth

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