Format

Send to

Choose Destination
See comment in PubMed Commons below
Otol Neurotol. 2012 Dec;33(9):1593-8. doi: 10.1097/MAO.0b013e318271c48b.

Otolithic membrane damage in patients with endolymphatic hydrops and drop attacks.

Author information

1
Departments of Head and Neck Surgery, University of California-Los Angeles, Los Angeles, California 90095, USA.

Abstract

OBJECTIVES:

1. Evaluate the otolithic membrane in patients with endolymphatic hydrops (EH) and vestibular drop attacks (VDA) undergoing ablative labyrinthectomy. 2. Correlate intraoperative findings to archival temporal bone specimens of patients with EH.

STUDY DESIGN:

Retrospective case review.

SETTING:

Tertiary referral center. SPECIMEN SOURCE: 1. Patients undergoing labyrinthectomy for incapacitating Ménière's disease (MD), delayed EH, VDA, or acoustic neuroma (AN) between 2004 and 2011. 2. Archival temporal bone specimens of patients with MD.

INTERVENTIONS:

Ablative labyrinthectomy.

MAIN OUTCOME MEASURES:

Examination of the utricular otolithic membrane.

RESULTS:

The otolithic membrane of the utricle was evaluated intraoperatively in 28 patients undergoing labyrinthectomy. Seven (25%) had a history of VDA, 6 (21%) had delayed EH, 9 (32%) had MD, and 6 (21%) had AN. All patients with VDA showed evidence of a disrupted utricular otolithic membrane, whereas only 50% and 56% of patients with delayed EH and MD, respectively, demonstrated otolithic membrane disruption (p = 0.051). None of the patients with AN showed otolithic membrane disruption (p = 0.004). The mean thickness of the otolithic membrane in 5 archival temporal bone MD specimens was 11.45 micrometers versus 38 micrometers in normal specimens (p = 0.001).

CONCLUSION:

The otolithic membrane is consistently damaged in patients with VDA. In addition, there is a significantly higher incidence of otolithic membrane injury in patients with MD and delayed EH compared with patients without hydrops, suggesting that the underlying pathophysiology in VDA results from injury to the otolithic membrane of the saccule and utricle, resulting in free-floating otoliths and atrophy.

PMID:
23064391
PMCID:
PMC5358090
DOI:
10.1097/MAO.0b013e318271c48b
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wolters Kluwer Icon for PubMed Central
    Loading ...
    Support Center