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Kidney Int. 2012 Nov;82(9):947-9. doi: 10.1038/ki.2012.254.

CD4+ Th1 cells are effectors in lupus nephritis--but what are their targets?

Author information

1
Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia.

Abstract

Lupus nephritis involves both humoral and cellular effectors. Okamoto and colleagues isolated renal CD4+ cells from lupus-prone mice, selecting cells expressing T-cell receptors on the basis of their activity. After transfecting CD4+ cells with the relevant T-cell receptors, they transferred them into mice and induced more severe glomerulonephritis. This study supports a direct role for Th1 cells in lupus nephritis, although their antigenic specificity remains uncertain, as they did not recognize nucleosomes.

PMID:
23064187
DOI:
10.1038/ki.2012.254
[Indexed for MEDLINE]
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