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Bioorg Med Chem Lett. 2012 Nov 15;22(22):6788-93. doi: 10.1016/j.bmcl.2012.09.044. Epub 2012 Sep 24.

Recent results in protein kinase inhibition for tropical diseases.

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Department of Chemistry and Biochemistry, Montclair State University, 1 Normal Avenue, Montclair, NJ 07043, United States.


Protein kinases are becoming widely investigated targets for treatment of protozoal parasitic tropical diseases such as malaria and leishmaniasis. The search for potent, selective inhibitors of these parasitic enzymes has been aided by the extensive variety of structures prepared for human diseases. Genomic approaches to target identification and validation have aided the search. Substantial progress has been made and research is continuing to expand in an effort to find safe, effective drug candidates for these difficult to treat and widespread diseases.

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