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Cell. 2012 Oct 12;151(2):246-8. doi: 10.1016/j.cell.2012.09.028.

The problem with mixing mitochondria.

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1
Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK. nick.lane@ucl.ac.uk

Erratum in

  • Cell. 2013 Jan 17;152(1-2):365.

Abstract

Mixing of mitochondrial DNAs (heteroplasmy) is unfavorable for reasons unknown. Sharpley et al. show that heteroplasmy has surprising genetic and behavioral effects in mice, even when each haplotype alone produces a normal phenotype. This interference is bioenergetic and may have contributed to the evolution of sexes.

PMID:
23063117
DOI:
10.1016/j.cell.2012.09.028
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